Resources
Explore Pharmaceutical Products Developed by Therapeutic Vision, Inc.
For over 20 years, our team at Omaha, Nebraska has been developing a variety of pharmaceutical products for vision, hearing and cognition. Learn more through our scientific publications.
Kinostat®
Kinostat® Could Be Man's Best Friend
Professor Peter F. Kador has developed topical Kinostat® to ameliorate the development and progression of cataracts in dogs with diabetes mellitus.
Topical Kinostat® Ameliorates the Clinical Development and Progression of Cataracts in Dogs With Diabetes Mellitus
This study was conducted to determine whether topical administration of the aldose reductase inhibitor Kinostat can ameliorate the onset or progression of cataracts in dogs with naturally occurring diabetes mellitus (DM).
Aldose Reductase, Ocular Diabetic Complications, and the Development of Topical Kinostat®
Diabetes mellitus (DM) is a major health problem with devastating effects on ocular health in both industrialized and developing countries. The control of hyperglycemia is critical to minimizing the impact of DM on ocular tissues.
Effects Of Topical Administration Of An Aldose Reductase Inhibitor On Cataract Formation In Dogs Fed A Diet High In Galactose
This study shows that the topical application of Kinostat® appears to arrest or reverse the development of experimentally induced sugar cataracts in dogs. This suggests that intervention with Kinostat® at the early stages of sugar cataract formation may be beneficial in maintaining or improving functional vision in dogs developing sugar cataracts.
Nutraceutical
Topical Nutraceutical Optixcare EH Ameliorates
A study based on the hypothesis that oral nutraceuticals do not adequately reach all ocular tissues in the anterior segment.
Multifunctional Redox Modulators (MFRM®)
A Vision of Eye Health – Counteracting Age-Related Changes in the Eye
Researchers from the University of Nebraska Medical Centre and Therapeutic Vision, Inc. have developed compounds that show promising potential to halt the progression.
Orally Bioavailable Metal Chelators and Radical Scavengers – Multifunctional Antioxidants for the Coadjutant Treatment of Neurodegenerative Diseases
In this study, it was found that oxidative stress results from an imbalance between oxidants such as reactive oxygen species (ROS), and antioxidants such as superoxide dismutase (SOD).
Orally Active Multifunctional Antioxidants Are Neuroprotective in a Rat Model of Light-Induced Retinal Damage
Progression of age-related macular degeneration has been linked to iron dysregulation and oxidative stress that induce apoptosis of neural retinal cells.
Effects of Multifunctional Antioxidants on Mitochondrial Dysfunction and Amyloid-Beta Metal Dyshomeostasis
Redox-active metal dyshomeostasis and oxidative stress are associated with mitochondrial dysfunction and amyloid-Beta neurotoxicity that are linked to both the development of age-related macular degeneration (AMD) and Alzheimer’s disease (AD). Studies demonstrate that MFRMs have metal attenuating properties with therapeutic potential in the treatment of both AMD and AD.
Orally Active Multifunctional Antioxidants Delay Cataract Formation in Streptozotocin (Type 1) Diabetic and Gamma-Irradiated Rats
Age-related cataract is a worldwide health care problem whose progression has been linked to oxidative stress and the accumulation of redox-active metals.
Multifunctional Antioxidants for the Treatment of Age-Related Diseases
A research on how oxidative stress damages cells and is an accepted determinant of both life span and health span. Oxidative stress results from the generation of reactive oxygen species.
NOVEL ORAL MULTIFUNCTIONAL ANTIOXIDANT PREVENTS NOISE-INDUCED HEARING LOSS AND HAIR CELL LOSS
MFRM HK-2 is a novel, safe, orally-deliverable and highly effective otoprotective compound with considerable promise for preventing hearing loss from noise and other hearing disorders linked to excessive oxidative stress. HK-2 dose-dependently reduces the amount of noise-induced hearing impairment as reflected by both cochlear compound action potentials and hair cell loss. In addition, it protects the viability of HEI-OC1 cells (a cochlear cell line) under diverse oxidative stress environments.
