Novel Oral Multifunctional Antioxidant Prevents Noise-Induced Hearing Loss and Hair Cell Loss
MFRM HK-2 is a novel, safe, orally-deliverable and highly effective otoprotective compound with considerable promise for preventing hearing loss from noise and other hearing disorders linked to excessive oxidative stress. HK-2 dose-dependently reduces the amount of noise-induced hearing impairment as reflected by both cochlear compound action potentials and hair cell loss. In addition, it protects the viability of HEI-OC1 cells (a cochlear cell line) under diverse oxidative stress environments.