Effects of Multifunctional Antioxidants on Mitochondrial Dysfunction and Amyloid-Beta Metal Dyshomeostasis
Redox-active metal dyshomeostasis and oxidative stress are associated with mitochondrial dysfunction and amyloid-Beta neurotoxicity that are linked to both the development of age-related macular degeneration (AMD) and Alzheimer’s disease (AD). Studies demonstrate that MFRMs have metal attenuating properties with therapeutic potential in the treatment of both AMD and AD.
Peter F. Kador received a PhD in Medicinal Chemistry from the Ohio State University and after a 25-year career at the National Institutes of Health retired as the Chief of the Laboratory of Ocular Therapeutics from the National Eye Institute. Prior to becoming Professor Emeritus, he served for 18 years as a professor at the College of Pharmacy and adjunct professor in the Departments of Ophthalmology, His work has been recognized with numerous national and international awards that include the Rhoto Cataract Research Award, Alcon Research Institute Award, Kinoshita Lectureship, Ernst H. Bárány Prize, UNMC Distinguished Scientist Award, Capital University Alumni Award, the Ohio State University College of Pharmacy Jack Beal Postbaccalaureate Alumni Achievement Award, and the Bundesverdienstkreuz (Federal Cross of Merit) from the German Government. He is a fellow of the American Association of Pharmaceutical Scientists, the Association for Research in Vision and Ophthalmology, Association of Ocular Pharmacology and Therapeutics, and an overseas fellow of the Royal Society of Medicine and a member of the American Health Council in Ophthalmology.